Everything above survival needs aren't needs. Further the distinction between safety and physiological needs is bunk. There are survival needs—the things without which you simply cannot be—and there is what you really want to do with your life. Without satisfying your survival needs, it'll be difficult to do what you really want to do. Some persons don't really have any special desires, so they'll be fine with just maximizing the satisfaction of their survival needs. I really only care about one thing, so that's what I built my life around. In terms of satisfying my needs, I figured a way to do that that's integrated with that lifestyle, so I never feel like I have to `work' to survive: I live in my own happy little world.>>975
The problem seems to be that what you're doing with your life is not what you really want to be doing with your life, or it is but there's something missing. You should know more about your life than I do, so I won't tell you what changes will work for you, but there are some general suggestions about how to figure it out. As banal as it sounds, trying different things tends to be a good place to start.
It could also be a mental health condition. If lifestyle changes don't improve your malaise, professional help may be beneficial.